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I've never used Zspheres in Zbrush so I though it was about time to to give them a try. There a little awkward at first, but after some trial and error (emphasis error) I worked out a decent biped. Hands and face are still an issue, the topo isn't very consistent in these areas and the hands have some definite weirdness. I saw a post somewhere about making quad hands correctly using zspheres. Next time I'll probably do more tuning but for a first time..... eh, not so bad.